Best Choline Supplements

If you’re reading this page, you may have been told by your doctor that you need to be taking a choline supplement.

Although choline is an essential nutrient, it wasn’t discovered until 1998, and it’s estimated that less than 10% of the United States population is getting enough of it. Apparently, the modern Western diet is just not providing enough of this essential nutrient. (1)

So that’s what we’ll be covering in this article: the best choline supplements available on the market.

But first, you may be wondering what choline is and if you should be taking it.

What is Choline and Should You be Taking a Choline Supplement?

As mentioned before, choline is an essential nutrient. It has a wide-ranging role in metabolism, cell structure, and neurotransmitter synthesis in human beings. (1)

In the twenty years since 1998 when choline became recognized as an essential nutrient, researchers have found several links between choline deficiency and diseases such as “liver disease, atherosclerosis, and, possibly, neurological disorders”. (1)

Choline is a water-soluble compound and has similar properties to vitamin B.

The human liver naturally produces some choline but very little of it, so the rest must be obtained through either regular diet or supplementation.

So should you take it? The bottom line is that you should be taking a choline supplement if you have a deficiency of it. You won’t benefit from taking a choline supplement if you don’t have a deficiency.

If you’ve determined with your doctor that you have a choline deficiency, here are the best choline supplements on the market.

#1: Double Wood Supplements Alpha GPC Choline Supplement

Image of a bottle of Double Wood Supplements Choline

The product that made it to the top of our best choline supplements list is the Double Wood Supplements Alpha GPC Choline Supplement. We noticed very high consumer satisfaction with this product, so we decided to investigate and were impressed with what we saw.

One of the most important things we like about this supplement is the type of choline used. This choline in this supplement comes in the form of Alpha GPC, which stands for l-alpha-glycerylphosphorylcholine. This is the most bioavailable form of choline, meaning it is more likely to be absorbed into the body.

It has 600 mg of Alpha GPC, which is a potent dose.

If there’s any supplement out on the market that is going to provide the health benefits associated with choline (i.e. enhanced memory and cognitive function), it’s this.

The only thing we don’t like about it is that it comes in a gelatin (animal-based) capsule, and you have to take two pills to get a serving.


  • Gives a good mental boost
  • Provides a feeling of energy
  • Comes in choline’s most bioavailable form


  • Can cause headaches in some
  • Capsule isn’t vegetarian-friendly
  • You have to take 2 pills for a serving

Active Ingredient Quality:


Average Consumer Rating:

Alpha GPC Choline Supplement (Beginner Nootropic for Brain Support, Focus, Memory, Motivation, and Energy) Pharmaceutical Grade, Made in USA (60 Capsules 300mg)
  • PROMOTE CHOLINE LEVELS - Alpha GPC is a highly bioavailable form of Choline which helps support healthy Choline levels
  • SUPPORT YOUR MEMORY - Remember more information for your exams, forget less deadlines at work, no more losing your car keys
  • SUPPORT ACETYLCHOLINE SYNTHESIS- Nootropics supplement to support memory, focus, and acetylcholine levels
  • MADE IN THE USA - Our Alpha GPC is manufactured right here in the USA
  • SAFETY TESTED IN THE USA - Double Wood's Alpha GPC is safety tested for heavy metals and microbes in New York

#2: Nature’s Way Choline and Inositol, 500mg

Image of a bottle of Nature's Way Choline & Inositol

Up next is Nature’s Way Choline and Inositol.

This product contains 500mg of choline and 500mg of inositol, which is good for mental health. (2) Researchers are currently in the process of determining whether inositol could be used in the regular treatment of psychological disorders such as anxiety and depression.

This product does come in a gelatin capsule, so it’s not vegan-friendly unfortunately.

On the other hand, it’s good that it doesn’t contain milk, lactose, yeast, wheat, sugar, soy, or preservatives. It has 100 capsules, so at 2 capsules per serving, that’s a 50-day supply.


  • Reasonable price
  • Has health benefits outside of just choline


  • Doesn’t come in l-alpha-glycerylphosphorylcholine form
  • Isn’t vegan-friendly

Active Ingredient Quality:


Average Consumer Rating:

Nature's Way Choline and Inositol, 500 mg per serving, 100 Capsules
  • Choline and Inositol help maintain cellular efficiency, proper nerve function and metabolism of fats and HDL (good) cholesterol
  • This product contains crystalline inositol and choline bound to tartaric acid
  • Gluten-Free

#3: Solgar Choline 350 MG

Image of a bottle of Solgar Choline 350 mg

Solgar has formulated their choline 350 mg supplement with healthy brain function in mind.

It contains 350 mg (as bitartrate), so it’s not the more easily absorbed type of choline that we’d like to see, but it’s not a deal breaker and it has some good things going for it still.

One of those being the supplement’s vegetable capsule, making it kosher and vegan-friendly. It’s also free of gluten, wheat, sugar, soy, dairy, yeast, sodium, and artificial colors or flavors.


  • Contains a balanced amount of choline
  • Comes in vegetarian capsules


  • Is not l-alpha-glycerylphosphorylcholine

Active Ingredient Quality:


Average Consumer Rating:

Solgar – Choline 350 mg, 100 Vegetable Capsules
  • WHAT IS CHOLINE: Choline is a member of the B Complex which is a component of cell membranes that provide key support to allow for cellular function at an optimal level
  • HOW IT WORKS: Choline is involved in the chemistry of the brain where it is used to synthesize acetylcholine. Acetylcholine is a critical neurotransmitter that is required for healthy brain function
  • ADDITIONAL SUPPORT: Choline is also known to provide support for the liver and it also has a role in promoting normal fat metabolism
  • KOSHER, GLUTEN FREE & SUITABLE FOR VEGETARIANS: These vegetable capsules are KOF-K Kosher certified, suitable for vegetarians and are certified gluten free. They are free of: gluten, wheat, dairy, soy, yeast, sugar, and sodium. They are also free of artificial flavors, sweeteners, preservatives and colors

#4: Flamingo Supplements – Choline Bitartrate Chewable Gummies

Image of a bottle of Flamingo Supplements Choline L-Bitartrate

Have trouble swallowing and/or digesting pills? Flamingo Supplements’ Choline Bitartrate Chewable Gummies may be a good option for you then.

This gummy supplement contains 100 mg of choline, which is 72% of the daily value. For most people, this is probably going to be plenty, considering the rest can be obtained easily through your diet.

As with most gummy supplements, it does contain sugar, but we were at least happy to learn that it’s made with organic cane sugar. These gummies are indeed tasty, and fortunately, the sugar levels are very low.

It also contains organic tapioca syrup. It does contain natural beta-carotene color.


  • Has plenty of choline
  • Great taste
  • Good option if you don’t like pills


  • Contains sugar
  • Contains artificial coloring

Active Ingredient Quality:


Average Consumer Rating:

Flamingo Supplements - Choline Bitartrate Chewable Gummies. Prenatal & Nootropic Benefits. Vegetarian, Delicious Lemon Flavor. 90 Count
  • THE BEST WAY TO TAKE YOUR CHOLINE GUARANTEED. Our delicious lemon flavored choline gummies are designed so that you look forward taking them. We guarantee you will love the taste of these gummies or your money back.
  • A QUALITY FORMULATION. Our choline L-bitartrate gummies contain very little sugar, and are made from quality ingredients like pectin which is plant based so it is suitable vegetarians. Plus they are non-GMO, made in the USA, and made in a FDA registered facility.
  • SUITABLE FOR WOMEN, MEN, & CHILDREN: Our gummies have very little sugar, use minimal ingredients, and are dosed conservatively so you can adjust to your needs accordingly. They are delicious and easily chewed.
  • ENJOY THE NOOTROPIC AND PRENATAL EFFECTS OF CHOLINE. Choline bitrartrate may improve memory, focus and mental clarity. It’s been shown to be so beneficial for prenatal brain development and cell building that doctors routinely prescribe it to expecting moms.*
  • A NAME YOU TRUST. Flamingo Supplements is a leader in the gummy industry specializing in gummies for kids and adults alike with high quality ingredients. We use clean ingredients like pectin and keep our formulations as simple as possible.

#5: Bulksupplements Choline L-Bitartrate Powder (250 grams)

Image of a bag of BulkSupplements Choline

Another good option if you don’t like taking pills is Bulksupplements Choline L-Bitartrate Powder. The choline in this supplement does come in the more bioavailable l-alpha-glycerylphosphorylcholine form.

This supplement comes in powder form that you can add to either food or drink.

A serving size of this supplement is 600 mg, which is a 1/4 teaspoon. This product contains 416 servings, so you get a lot of bang for your buck.

It doesn’t have any dairy, soy, sugar, yeast, gluten, or any additives.

One issue with this product is that the powder gets bounced around in transit and can get lodged in the plastic zipper seal, making it difficult to close. One Amazon reviewer mentioned picking out the powder with a toothpick, which we tried and it worked well.


  • Very good value for the price
  • Good alternative to choline in pill form
  • Is mostly tasteless so it mixes well with food, shakes, and other drinks


  • Can be difficult to seal the bag it comes in

Active Ingredient Quality:


Average Consumer Rating:

Bulksupplements Choline DL-Bitartrate Powder (250 grams)
  • Clean & pure powder
  • Lab tested for verification & guaranteed purity
  • Maintains overall heart health
  • Increases physical endurance
  • Protects against free radicals


As with most supplements, finding the best choline supplement for you is a personal process. There are little things here and there that may make the perfect supplement for you not work out so well for someone else.

So for a one-size-fits-all type of choline supplement that’s going to work for a large number of people, the Double Wood Supplements Alpha GPC Choline Supplement is a fantastic option. It’s a little more expensive than some of the competition, but in many cases, it’s just costlier for manufacturers to use high-quality ingredients. You get what you pay for.

If you’re on a budget, supplements 2, 3, and 5 are great options. If you prefer not taking pills, option 4 or 5 might be the best choice.

Do you have any experience with the choline supplements listed here? Let us know in the comments section and tell us about your experience.


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